gene regulation, chromatin structure and dynamics, and nuclear organization

2025

1. PNAS

   

   Immiscible proteins compete for RNA binding to order condensate layers

   Wilton T. Snead^c, Mary K. Skillicorn, Krishna Shrinivas^c, and Amy S. Gladfelter^c

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   This work was covered by Northwestern McCormick, and Marine Biological Laboratories. Science Magazine highlights our work!

2023

1. Nat. Comm

   

   A model for organization and regulation of nuclear condensates by gene activity

   Halima H. Schede⁼, Pradeep Natarajan⁼, Arup K. Chakraborty, and Krishna Shrinivas^c

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2021

1. Cell

   

   RNA-Mediated Feedback Control of Transcriptional Condensates

   Jonathan E. Henninger⁼, Ozgur Oksuz⁼, Krishna Shrinivas⁼, Ido Sagi, Gary LeRoy, Ming M. Zheng, J. Owen Andrews, Alicia V. Zamudio, Charalampos Lazaris, Nancy M. Hannett, Tong Ihn Lee, Phillip A. Sharp, Ibrahim I. Cissé, Arup K. Chakraborty^c, and Richard A. Young^c

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   This work was covered by: Whitehead Institute, Physics Today

2019

1. Mol. Cell

   

   Enhancer features that drive formation of transcriptional condensates

   Krishna Shrinivas⁼, Benjamin R Sabari⁼, Eliot L Coffey, Isaac A Klein, Ann Boija, Alicia V Zamudio, Jurian Schuijers, Nancy M Hannett, Phillip A. Sharp, Richard A. Young^c, and Arup K. Chakraborty^c

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   This work was covered by: MIT news, Genetic Eng. and Biotech News,

2018

1. Science

   

   Coactivator condensation at super-enhancers links phase separation and gene control

   Benjamin R Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A Klein, Eliot L Coffey, Krishna Shrinivas, Brian J Abraham, Nancy M Hannett, Alicia V Zamudio, John C Manteiga, and  others

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   This work was covered by: Whitehead News, ScienceNews, and was recognized as 1 of 10 Science breakthroughs of 2018. A perspective piece was also published covering this and related work in Science.

2017

1. Cell

   

   A phase separation model for transcriptional control

   Denes Hnisz⁼, Krishna Shrinivas⁼, Richard A Young^c, Arup K Chakraborty^c, and Phillip A Sharp^c

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