Shrinivas lab

Chemical & Biological Engineering , Northwestern University

Adapted from original art of David Goodsell

Vision

The lab’s vision is to understand and engineer how life works at the molecular and cellular scales. The functions of life emerge from dynamic interactions amongst billions of biomolecules that self-organize in a crowded and squishy cellular environment. We thus adopt an interdisciplinary approach - bridging ideas across biophysics, chemistry, computer science, and engineering to decipher fundamental scientific mechanisms while also pursuing translational applications to impact human health. This approach is bolstered by our extensive local ties (NU Medical School, Applied Math, Center for Synthetic Biology, National Institute for Theory and Math in Biology) and broader collaborations with scientists across the country. Towards and beyond the science, we believe in fostering an environment that supports the well-being and success of all members.

If you are interested in learning more - check out our research, papers, or open positions.

Latest news

May 06, 2026 Krishna gave a seminar at Caltech’s Division of Biology and Biological Engineering on the role of condensates in cellular decision-making. Many thanks to Erik Winfree for hosting a memorable visit and science-filled strolls amidst lavender hued jacaranda trees.
Mar 31, 2026 The winter quarter ends:
  • The lab successfully escaped an ancient temple and celebrated with froyo!
  • Neha gave a talk at the Science with Seniors Event organized by SPOT at the Levy center.
  • Angie Lee and Andrea Kormaz receive fellowships from DeFeo Foundation and McCormick SURG for their summer research.
Feb 28, 2026 Neha and Mary gave a lab tour and shared their passion for science (with phase separation props) with middle and high school students during the Career Day for Girls event organized by the Society of Women Engineers (with Angie helping organize the event!).

selected publications

  1. Generalized design of sequence-ensemble-function relationships for intrinsically disordered proteins
    Ryan Krueger, Michael P Brennerc, and Krishna Shrinivasc
  2. Information processing driven by multicomponent surface condensates
    Aidan Zentner, Ethan V Halingstad, Cameron Chalk, Michael P BrennerArvind MuruganErik Winfree, and Krishna Shrinivasc
  3. Immiscible proteins compete for RNA binding to order condensate layers
    Wilton T. Sneadc, Mary K. Skillicorn, Krishna Shrinivasc, and Amy S. Gladfelterc