Shrinivas lab

Chemical & Biological Engineering , Northwestern University

Adapted from original art of David Goodsell

Vision

The lab’s vision is to understand and engineer how life works at the molecular and cellular scales. The functions of life emerge from dynamic interactions amongst billions of biomolecules that self-organize in a crowded and squishy cellular environment. We thus adopt an interdisciplinary approach - bridging ideas across biophysics, chemistry, computer science, and engineering to decipher fundamental scientific mechanisms while also pursuing translational applications to impact human health. This approach is bolstered by our extensive local ties (NU Medical School, Applied Math, Center for Synthetic Biology, National Institute for Theory and Math in Biology) and broader collaborations with scientists across the country. Towards and beyond the science, we believe in fostering an environment that supports the well-being and success of all members.

If you are interested in learning more - check out our research, papers, or open positions.

Latest news

May 28, 2026 The lab’s work on computational design of dynamic biomolecules called intriniscally disordered proteins makes the cover of Nature Computational Science!
May 22, 2026 Krishna gives (different) talks at 2 fun meetings in Germany - IDEAS explored themes of decision-making by phase transitions and EMBO meeting was on condensates and gene activity. Thanks to organizers for invites and planning great meetings.
May 15, 2026 The lab participated and celebrated the 10 year anniversary for the Center for Synthetic Biology and the trainee-focused retreat!

selected publications

  1. Generalized design of sequence-ensemble-function relationships for intrinsically disordered proteins
    Ryan Krueger, Michael P Brennerc, and Krishna Shrinivasc
  2. Information processing driven by multicomponent surface condensates
    Aidan Zentner, Ethan V Halingstad, Cameron Chalk, Michael P BrennerArvind MuruganErik Winfree, and Krishna Shrinivasc
  3. Immiscible proteins compete for RNA binding to order condensate layers
    Wilton T. Sneadc, Mary K. Skillicorn, Krishna Shrinivasc, and Amy S. Gladfelterc