Shrinivas lab

Chemical & Biological Engineering , Northwestern University

Adapted from original art of David Goodsell

Vision

The lab’s vision is to understand and engineer how life works at the molecular and cellular scales. The functions of life emerge from dynamic interactions amongst billions of biomolecules that self-organize in a crowded and squishy cellular environment. We thus adopt an interdisciplinary approach - bridging ideas across biology, physics, computer science, and engineering to decipher fundamental scientific mechanisms while also pursuing translational applications to impact human health. This approach is bolstered by our extensive local ties (NU Medical School, Applied Math, Center for Synthetic Biology, National Institute for Theory and Math in Biology) and broader collaborations with scientists across the country. Towards and beyond the science, we believe in fostering an environment that supports the well-being and success of all members.

If you are interested in learning more - check out our research, papers, or open positions.

Latest news

Aug 29, 2025 Jackson Boodry receives a fellowship from the Molecular Biophysics Training Grant program that supports his research melding machine learning, statistical physics, and protein dynamics.
Aug 28, 2025 Lab is excited to receive support from the NITMB for an interdisciplinary research project to develop models to chart how the genome and condensates are organized in the nucleus - led by Kaden DiMarco in collaboration with our NU colleagues Yue Yang and Tomoko Yamada.
Aug 12, 2025 The lab’s paper dissecting mechanisms of paraspeckle formation is published in PNAS, along with accompanying coverage from Northwestern McCormick, Feinberg, and MBL!

selected publications

  1. Immiscible Proteins Compete for RNA Binding to Order Condensate Layers
    Wilton T. Sneadc, Mary K. Skillicorn, Krishna Shrinivasc, and Amy S. Gladfelterc
  2. Generalized Design of Sequence-Ensemble-Function Relationships for Intrinsically Disordered Proteins
    Ryan Krueger, Michael P Brennerc, and Krishna Shrinivasc